SB 452533 ( —— )

Catalog No. M27705 CAS No. 459429-39-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

SB 452533
Note

Research use only, not for human use.
Brief Description

SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8).
Description

SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8).(In Vitro):SB 452533 significantly reduced Capsaicin-induced phosphorylation of AMPK and CAMKK2.(In Vivo):Small dose Cap significantly reduced bleomycin-induced pulmonary fibrosis in mice and obviously reversed alveolar epithelial cells epithelial-mesenchymal transition (EMT) (the expression of E-cadherin and ZO-1 were increased(P＜0.05 or P＜0.01)and the expression of α-SMA and Vimentin were decreased (P＜0.05 or P＜0.01) after drugs treatment for 21 day, concomitantly with the increase the expressions of TRPV1 and CGRP (P＜0.05 or P＜0.01), and inhibiting ERK1/2 phosphorylation and eIF3a expression (P＜0.05 or P＜0.01). These effects of small dose Cap were abolished in the presence of TRPV1 receptor antagonist SB 452533.
Synonyms

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Pathway

Membrane Transporter/Ion Channel
Target

TRP/TRPV Channel
Recptor

NF-κB;p65
Research Area

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Indication

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1.A new xanthone from the pericarp of Garcinia mangostana. Nat Prod Commun. 2013 Dec;8(12):1733-4.

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